Description
Bacillus subtilis
Bacillus subtilis is a gram positive, spore-forming bacterium that can be found in soil, water, and other environments. It has been extensively studied due to its potential use in agriculture, biotechnology, and as a probiotic. It is also capable of producing a wide range of enzymes, antibiotics, and other metabolites that have industrial and therapeutic applications. It forms endospores which protects the bacterium from harsh environmental conditions. It can also switch from motile to a sessile lifestyle, forming biofilms that are resistant to antibiotics and environmental stresses. It can grow in a wide range of temperatures and pH and can survive in the presence of oxygen or in anaerobic conditions. Although commonly used in laboratory studies, Bacillus subtilis is mainly utilised for genetic research rather than health research, due to its high susceptibility to genetic mutation, making it a valuable tool in experimental settings.
Scientific research suggests that Bacillus subtilis offers numerous health benefits. It may aid in weight loss by reducing obesity, possess antioxidant properties, positively adjust gut microbiota, and help lower cholesterol levels. Bacillus subtilis may also be useful in managing diabetes, relieving constipation, and treating diarrhoea, as well as diarrhoea-predominant or alternating types of irritable bowel syndrome (IBS). Additionally, it may be beneficial in inflammatory bowel disease (IBD) and combating H pylori infections. Bacillus subtilis can stimulate the immune system, fight against infections and fungal infections, and help with liver disorders. It also has skin healing properties and can aid in the treatment of periodontitis. Furthermore, polysaccharides derived from Bacillus subtilis spores may help reduce the risk of cardiovascular disease in diabetics, while Bacillus subtilis itself may combat Candida albicans infections (1).
Epigenetics probiotic Bacillus subtilis is produced in a vegan friendly and convenient delayed release capsule. Recommended daily dose is 1 serving per day taken after a meal, or as directed by a healthcare practitioner. This product is not intended to be used as an alternative to a varied diet.
Ingredients
| Ingredient |
Amount per serving |
ECRDA* |
%DV* |
| Inulin (from Jerusalem artichoke) |
330 mg |
† |
† |
| Bacillus subtilis |
100 mg (≥5B CFU) |
† |
† |
† Percent Daily Reference Intakes (RI) not established.
INGREDIENTS: Organic Jerusalem artichoke tuber extract (Helianthus tuberosus), Delayed release vegetable capsule (Hydroxypropyl methylcellulose, Gellan gum), Bacillus subtilis.
Suitable for vegans
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Research has demonstrated that Bacillus subtilis and other soil-based bacteria can provide significant benefits for gut issues, particularly IBS. While Bacillus coagulans are the most extensively researched strain in treating IBS, other species like Bacillus subtilis have also been shown to help alleviate IBS symptoms, including bloating, cramping, abdominal pain, nausea, urgency, and diarrhoea. Moreover, patients diagnosed with IBS reported an improvement in their quality of life and a decrease in anxiety and depression after using soil-based probiotics. These benefits can be further enhanced when soil-based probiotics are used with treatments, such as a low FODMAP diet or medications designed to reduce bloating and abdominal pain. Bacillus probiotics also offer benefits for other gut issues, including chronic constipation and diarrhoea, and can even protect against side effects commonly experienced with antibiotic use (2).
Soil-based probiotics are useful in restoring the balance of gut bacteria. They can effectively combat harmful bacteria in the gastrointestinal tract such as C. difficile and H. pylori infections, particularly when combined with conventional antibiotic therapy. Their ability to fight off these pathogens and colonise the GI tract makes them effective in restoring the natural microbiome of the digestive system. Their potential to reinstate gut microflora is likely a reason why they are beneficial when used alongside other therapies to alleviate symptoms of small intestine bacterial overgrowth (2).
Bacillus subtilis has been shown to play a role in aiding the management of diabetes (3). Recent research on patients with type two diabetes who were refractory to traditional treatments has revealed that probiotic supplementation with Bacillus subtilis may help improve glycaemic control (4). The link with diet and the development of type one diabetes has also been studied, highlighting the potential for the use of Bacillus subtilis in the prevention and management of the disease (1). Diabetes mellitus has many complications, however, the use of Bacillus subtilis may help mitigate some of the effects associated with the disease, as well as improve glycaemic control.
Bacillus subtilis has emerged as the most critical microbe for vitamin K2 synthesis, owing to its numerous benefits, including rapid proliferation, straightforward cultivation, and remarkable vitamin K2 levels. Menaquione-7 (MK-7) is the primary form of vitamin K2 synthesised by Bacillus subtilis natto (5) and it plays an important role in the gut (6). Studies have shown that MK-7 is biosynthesised from Bacillus subtilis (7, 8) further highlighting the role this bacterium plays in making vitamin K2.
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