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Item Number: 3545

Bifidobacterium Bifidum pack of 60 capsules *

£29.80 Exc. VAT

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P U R E  •  T R U S T E D  •  V E G A N

+ Purest Formulas
Here at Epigenetics, the quality and purity of each ingredient is integral to our development of effective, bioavailable formulas. Our products are naturally pesticide-free and completely free from artificial fillers, additives, lubricants, binders, bulking agents and preservatives.

+ Trusted Quality
Proudly made in our UK based production facility, set in the heart of the countryside. Your trust in us matters, and as such, we adhere to the strictest GMP regulations and guidelines when producing all of our products.

+ Vegan Friendly
We respect nature and as such we do our part and only use vegan-friendly ingredients in our Bifidobacterium Bifidum.

+ Letterbox Friendly
Our capsules come in small postal packs, designed for easy, contact-free delivery. The smaller design leads to a reduced carbon footprint during the shipping process.

+ FDA Compliant 
* – An FDA compliant product – can be shipped to the USA

Please be aware that due to the nature of our probiotic products, we will not be able to receive this item back should you wish to return it. For this reason it’s advised that you take care when ordering, as we may not be able to offer you a refund.


Bifidobacterium bifidum

Bifidobacterium bifidum is a gram-positive bacterium that is commonly found in the human gastrointestinal tract (1). It plays an important role in promoting immune system development and function, maintaining the microflora balance within the intestines, and aiding the digestive process (2).  Bifidobacterium bifidum has also been shown to have a range of beneficial effects on human health including the prevention and treatment of various gastrointestinal disorders such as infectious diarrhoea, irritable bowel syndrome, and ulcerative colitis. It may also have a positive effect on eczema in infant and treatment from Helicobacter pylori infection (1).

If you have a weakened immune system, please consult your health care practitioner before using this product.

Epigenetics probiotic Bifidobacterium bifidum is produced in a vegan friendly and convenient delayed release capsule. Recommended daily dose is 1 serving per day taken after a meal, or as directed by a healthcare practitioner. This product is not intended to be used as an alternative to a varied diet.


Ingredient Amount per serving ECRDA* %DV*
Inulin (from Jerusalem artichoke) 350 mg
Bifidobacterium bifidum 50 mg (5B CFU)

† Percent Daily Reference Intakes (RI) not established.

INGREDIENTS: Organic Jerusalem artichoke tuber extract (Helianthus tuberosus), Delayed release vegetable capsule (Hydroxypropyl methylcellulose, Gellan gum), Bifidobacterium bifidum.

Suitable for vegans

Read More

Bifidobacterium bifidum is a beneficial bacterium that naturally resides in the human gut. It is particularly important for aiding in digestive health because it helps to break down food particles and convert them into nutrients that the body can use. Bifidobacterium bifidum also helps regulate the balance of microorganisms in the gut, promoting the growth of other beneficial bacteria while inhibiting the growth of harmful ones. This helps prevent digestive issues such as bloating, gas, and constipation. Moreover, Bifidobacterium bifidum can strengthen the intestinal barrier, which helps to prevent the leakage of harmful substances into the bloodstream.

Numerous studies focus on infant nutrition and the potential of Bifidobacterium bifidum to boost the immune response of premature or weakened digestive systems in new-borns. One study examined the impact of Bifidobacterium bifidum on neonatal necrotizing enterocolitis (NEC), a leading cause of mortality in premature infants, and yielded promising results. The study involved premature rats subject subjected to conditions that induced NEC. In a controlled setting, Bifidobacterium bifidum led to a decrease in NEC occurrence from 57% in the control group to 17% in the study group. These findings suggest that Bifidobacterium bifidum, which is abundant in breast milk, may alleviate inflammation and regulate the mucus layer to enhance digestion in infants (3).

Bifidobacterium bifidum also has a positive impact on the immune system. It is known to be involved in modulating different pathways that involve both innate and adaptive immunity (4). Researchers observed that various strains of the bacteria possess the ability to impact the immune system. Certain strains can enhance immunity by enlisting white blood cells to combat an infection, while others can diminish the inflammation by enlisting fewer white blood cells (1).

Another investigation explored the impact of Bifidobacterium bifidum on managing allergic conditions in new-borns from families with a history of eczema. The study involved administrating a probiotics formulation containing Bifidobacterium bifidum to mothers before delivery and to their babies for a year postpartum, while a control group received no probiotic treatment. Until the infants reached three months of age, the occurrence of eczema was much more prevalent in the placebo group than in the intervention group. Moreover, the preventive effects continued in the intervention group until the children turned two years old (5). This highlights the role Bifidobacterium bifidum may play on eczema in infants.

Likewise, recent research has indicated that Bifidobacterium bifidum may have potential in managing allergic responses. In a study where mice were administered an oral dose of this probiotic to evaluate its impact on immunoglobulin E production, researchers observed a robust suppressive effect. As a result, they concluded that Bifidobacterium bifidum could serve as a valuable tool in managing illnesses triggered by allergic reactions (6).

Furthermore, Bifidobacterium bifidum has been shown to have a positive impact on cholesterol levels (1). Research suggests that this bacterium may be able to reduce levels of low-density lipoprotein (LDL) cholesterol, as demonstrated by experiments in which Bifidobacterium bifidum was able to assimilate LDL cholesterol synthetic growth media (7). However, more research is needed on this.

People with weakened immune systems for example those with HIV, AIDS or undergoing chemotherapy should talk to their healthcare practitioner before using this product as it can possibly lead to infections (1).

Product Information

Packaging: 60 capsules

Recommended daily dose, 1 serving taken after a meal.

Serving size: 1 capsule, Servings per container: 60

Store in a refrigerator out of reach and sight of children. Once opened, consume within 6 months.



  1. Duggal, N. (2017) Bifidobacterium bifidum: Benefits, side effects, and more, Healthline. Healthline Media. Available at: (Accessed: March 2, 2023).
  2. Montrose, D. C., & Floch, M. H. (2005). Probiotics used in human studies. Journal of clinical gastroenterology39(6), 469–484.
  3. Khailova, L., Dvorak, K., Arganbright, K. M., Halpern, M. D., Kinouchi, T., Yajima, M., & Dvorak, B. (2009). Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. American journal of physiology. Gastrointestinal and liver physiology297(5), G940–G949.
  4. Ruiz, L., Delgado, S., Ruas-Madiedo, P., Sánchez, B., & Margolles, A. (2017). Bifidobacteria and Their Molecular Communication with the Immune System. Frontiers in microbiology8, 2345.
  5. Niers, L., Martín, R., Rijkers, G., Sengers, F., Timmerman, H., van Uden, N., Smidt, H., Kimpen, J., & Hoekstra, M. (2009). The effects of selected probiotic strains on the development of eczema (the PandA study). Allergy64(9), 1349–1358.
  6. Ohno, H., Tsunemine, S., Isa, Y., Shimakawa, M., & Yamamura, H. (2005). Oral administration of Bifidobacterium bifidum G9-1 suppresses total and antigen specific immunoglobulin E production in mice. Biological & pharmaceutical bulletin28(8), 1462–1466.
  7. Zanotti, I., Turroni, F., Piemontese, A., Mancabelli, L., Milani, C., Viappiani, A., Prevedini, G., Sanchez, B., Margolles, A., Elviri, L., Franco, B., van Sinderen, D., & Ventura, M. (2015). Evidence for cholesterol-lowering activity by Bifidobacterium bifidum PRL2010 through gut microbiota modulation. Applied microbiology and biotechnology99(16), 6813–6829.


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