Description
Inositol
Inositol is a vital nutrient that plays various essential functions in the body and brain. In particular, inositol has been shown to have a wide range of biological and psychological functions. One crucial role of inositol is its ability to break down harmful fats and remove them from the liver. Additionally, it has been found to lower low density lipoprotein cholesterol levels and raise high density lipoprotein cholesterol levels, while also reducing triglyceride levels. Inositol has been demonstrated to be beneficial for individuals with polycystic ovary syndrome (PCOS), helping to improve symptoms such as weight loss and increased ovulation frequency. The nutrient is also essential for promoting strong, healthy hair growth and enhancing brain cell health. Inositol works in conjunction with choline to form lecithin, a crucial building block for cellular membranes, and allows for the synthesis of the myelin sheaths that protect neurons. Furthermore, inositol has been shown to enhance the signalling capacity of major neurotransmitters, making it an important nutrient for maintaining cognitive function and emotional well-being (1).
The optimal daily value for inositol remains uncertain due to a lack of consensus among regulatory bodies regarding its nutritional value. As a result, there is no established nutrient reference value for this compound. Nonetheless, scientific studies suggest that inositol may be advantageous in quantities as substantial as 18g per day (2).
Inositol is naturally synthesised by the human body in small amounts and deficiency can occur if adequate dietary sources are not consumed. Prolonged use of antibiotics can lead to a reduction in inositol stores, and the long-term administration of lithium can hinder the enzyme necessary for inositol synthesis. Symptoms of inositol deficiency include alopecia, vision or eye abnormalities, fatty liver, memory loss, constipation, elevated levels of LDL cholesterol, eczema, and atherosclerosis. It is essential to monitor inositol levels, particularly in individuals receiving long-term lithium treatment or prolonged antibiotic use, to prevent the associated manifestations of inositol deficiency. Supplementation may be required to maintain adequate inositol levels (1).
If pregnant or breastfeeding, or taking antidiabetic drugs, please consult your healthcare practitioner before use.
Epigenetics Inositol is produced in a convenient, vegan friendly capsule. Recommended daily dose is 1 serving per day taken with a meal, or as directed by a healthcare practitioner. This product is not intended to be used as an alternative to a varied diet.
Ingredients
| Ingredient |
Amount per serving |
ECRDA* |
%DV* |
| Inositol |
500 mg |
† |
† |
† Percent Daily Reference Intakes (RI) not established.
INGREDIENTS: Inositol, Vegetable capsule (Hydroxypropyl methylcellulose).
Suitable for vegans
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Inositol, a sugar alcohol found in various food sources, has been shown to modulate the activity of several neurotransmitters in the brain, including serotonin and dopamine, which are known to regulate mood and behaviour. Interestingly, studies have revealed that individuals suffering from depression, anxiety, and compulsive disorders exhibit lower levels of inositol in their brain, suggesting that it may play a crucial role in the pathophysiology of these mental health conditions. While further investigations are warranted, multiple studies have suggested that inositol may serve as a promising alternative therapy for such disorders with fewer side effects than traditional medications. Panic disorder, a severe form of anxiety, is among the mental health conditions that have been studies in the context of inositol supplementation. In a month-long trial, individuals taking 18 grams of inositol per day experienced fewer panic attacks per week than those taking conventional anxiety medication. Moreover, in a similar study, patients reported a decrease in the frequency and severity of panic attacks after supplementing with 12 grams of inositol per day for four weeks (3).
Similarly, depression is a mental disorder that has been studied in the context of inositol supplementation with inconclusive outcomes. A previous investigation reported encouraging findings, wherein depressed individuals who consumed a 12-gram daily inositol supplement for four weeks showed symptomatic improvement. This suggests that inositol might have implications in mental health (3).
The effects of inositol on bipolar disorder have been minimally explored, yet early observations show promise. A limited study on paediatric patients diagnosed with bipolar spectrum disorders found that a combination of 3 grams of omega 3 fatty acids and up to 2 grams of inositol daily for 12 weeks led to a decrease in manic and depressive symptoms. Additionally, investigations have revealed that a daily consumption of 3-6 grams of inositol could mitigate psoriasis symptoms triggered by lithium, a common medication prescribed for bipolar disorder. These findings propose that inositol may hold potential in managing bipolar disorder (3).
Inositol may play a role in helping to manage PCOS. Research suggests that inositol supplements may provide relief for symptoms of PCOS, particularly when taken in conjunction with folic acid. Clinical studies have suggested that daily doses of inositol and folic acid can help reduce levels of triglycerides in the bloodstream, improve insulin function, and slightly lower blood pressure in individuals with PCOS. Moreover, preliminary research has demonstrated that the combination of inositol and folic acid may promote ovulation in women who experience fertility issues due to PCOS. In one study, a daily intake of 4 grams of inositol and 400 mcg of folic acid for 3 months resulted in ovulation in 62% of treated women (3).
Insulin plays a crucial role in regulating blood sugar levels in the body, and insulin resistance is a significant factor in conditions such as metabolic syndrome. Inositol has been studied for its potential to improve insulin sensitivity and reduce insulin resistance. This is because inositol can produce molecules that are involved in insulins action within cells. Several studies have found that inositol can improve insulin sensitivity and blood sugar control. For instance, a six-month study involving 80 postmenopausal women with metabolic syndrome found that 4 grams of inositol per day improved insulin sensitivity, blood pressure, and cholesterol levels more than a placebo. Additionally, research has shown that inositol can also benefit women with gestational diabetes. Although the results are mixed, some studies suggest that inositol may improve insulins action in women with PCOS (4).
Similarly, insulin sensitivity has been identified as a factor that can affect fertility in women with PCOS. Inositol, which can improve insulin sensitivity, has been investigated as a potential treatment for this population. Studies have shown that inositol can enhance ovarian function and fertility in women with PCOS. The studies have utilised doses ranging from 2-4 grams per day and have reported improvements in menstrual cycle regularity, ovulation, and pregnancy rates in normal-weight, overweight, and obese women. Therefore, inositol supplementation may be a promising approach to improving fertility outcomes in women with PCOS (4).
While generally safe, there is a potential interaction between inositol and antidiabetic drugs. Inositol has been shown to possess blood sugar lowering properties, and therefore, concurrent administration of inositol with medications for diabetes may result in excessive reduction of blood glucose levels. Close monitoring of blood sugar levels is advised in individuals taking these drugs alongside inositol to prevent hypoglycaemia (5).
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